CIRMTV Videos

The FDA requires the use of a Good Manufacturing Practice (GMP) facility for taking stem cell-based therapies into clinical trials. This GMP facility is a clean-room laboratory that ensures the therapeutic products will be safe and contamination-free for patients. In Spring 2008, CIRM gave $272 million for the construction of twelve stem cell research facilities in California. The University of California, Davis was one of the recipients of this Major Facilities grant. Their $20 million ...

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Macular degeneration is a disease associated with aging that gradually destroys sharp central vision, making it impossible to see faces, to read, or to drive. No therapy exists for the most common, or "dry", form of the disease. Mark Humayun, professor of ophthalmology & biomedical engineering at the Doheny Eye Institute, University of Southern California, recently received a CIRM Disease Team Award to develop a stem cell-based therapy for Macular Degeneration.

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On September 23rd 2009, the world celebrated Stem Cell Awareness Day. In California, scientists across the state visited high schools to teach students about the recent advances in stem cell research and the future promise of stem cell-based therapies. Ellen Robey, a professor of immunology and pathogenesis at the University of California, Berkeley, spoke to students at El Cerrito High School.

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Parkinson's disease is a neurodegenerative disease that affects nearly a million people in the United States. The symptoms include tremors, slow movement, muscle rigidity and less facial expression. No cure exists for the disease and current medications become less effective over time. William Langston, CEO and scientific director of the Parkinson's Institute, discusses stem cell-based research strategies to better understand the disease and to find new therapies. The Parkinson's Institute ...

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Myeloid proliferative diseases are life threatening blood disorders that can lead to acute leukemia. Using stem cells, the laboratory of Dr. Catriona Jamieson showed that a specific small molecule could halt these diseases. This work, funded in part by the California Institute for Regenerative Medicine, led to a clinical trial, which is now underway. In this video, three of the clinical trial participants talk about their remarkable results using this drug. Jamieson is assistant professor of ...

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The California Institute for Regenerative Medicine, the state stem cell agency, requires ethics training for all grantees. Mary Devereaux runs the ethics training program for the San Diego ethics consortium, which is made up of four research institutes in San Diego.

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Researchers at the University of California, Irvine have reversed Alzheimers-like symptoms in mouse models of the disease with injections of neural stem cells. The first author, Mathew Blurton-Jones, has a Training grant from the California Institute for Regenerative Medicine. The lead author, Frank laferla, has a SEED grant and an Early Translational grant from CIRM.

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Organizations outside the United States have begun advertising stem cell-based cures for disease, and in increasing numbers Americans are traveling to receive these cures. Unfortunately, at this time none of those advertised therapies have been shown to be either safe or effective. Researchers such as Jeanne Loring, director of the Center for Regenerative Medicine at the Scripps Research Institute, worry that people could be harmed through the untested procedures that they receive when they ...

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Researchers funded by CIRM developed a novel way of generating induced pluripotent stem (ips) cells. The technique involves a genetic molecule called a microrna to activate genes required to reprogram the adult cell to a state similar to an embryonic stem cell. The authors think micrornas could make existing methods for creating those cells -- either with inserted DNA or chemical baths -- more efficient, and could also prevent the reprogramming that takes place when a normal cell becomes ...

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CIRM funded 12 new research facilities in California, a $272 million investment that leveraged $1.1 billion in donor and institutional funding. This funding has already created construction jobs for the buildings, many of which are expected to be completed in the next two years. Once built, the additional space will provide room for new faculty members and create jobs for laboratory personnel. The buildings are all designed to speed the translation of basic science to human trials by ...

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