The Art of Vinculin Activation

to cell adhesions of the extracellular membrane. The protein has a globular head domain that contains binding sites for talin, α-actinin and a tyrosine phosphorylation site. The tail region contains binding sites for F-actin, paxillin, and regulatory lipids Integrins are coupled to the actin cytoskeleton by a series of actin-binding proteins including vinculin. Upon loss of its intramolecular head-tail interaction, vinculin transitions from its closed, inactive conformation to its open, ...
Author: midoriissa; Tags: biochemstry dance vinculin talin actin focal adhesion


















